Volume 28, No 2, Feb 2018

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 28 Issue 2, February 2018: 139-140

RESEARCH HIGHLIGHTS

New traffic light on Th17 Avenue

Hao Xu¹, Dan R Littman^{1, 2}

¹Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA;
² The Howard Hughes Medical Institute, USA Correspondence: Dan R Littman(Dan.Littman@med.nyu.edu)

Activation of STAT3-coupled receptors along with TGF-β signaling are fundamental for Th17 cell differentiation both in vivo and in vitro. A recent paper shows that TGF-β signaling relieves SKI-mediated transcriptional repression of Rorc, the key regulator of the Th17 program.

10.1038/cr.2017.156

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