Volume 28, No 2, Feb 2018
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 28 Issue 2, February 2018: 253-256
LETTERS TO THE EDITOR
m6 A mRNA methylation sustains Treg suppressive functions
Jiyu Tong1,2,*, Guangchao Cao2,3,*, Ting Zhang1,*,Esen Sefik2, Maria Carolina Amezcua Vesely2,James P Broughton6, Shu Zhu4, Huabin Li5, Bin Li1, Lei Chen1, Howard Y Chang6, Bing Su1,2,Richard A Flavell2,7, Hua-Bing Li1,2
1Shanghai Institute of Immunology, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai 200025, China;
2 Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA;
3 The First Affiliated Hospital, Biomedical Translational Research Institute and Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou, Guangdong 510632, China;
4 Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui 230027, China;
5 Department of Otolaryngology, Head and Neck Surgery, Affiliated Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai 200031, China;
6 Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA;
7 Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA
Correspondence: Hua-Bing Li,E-mail: huabing.li@shsmu.edu.cn； Richard A Flavell，(E-mail: richard.flavell@yale.edu)
N6-methyladenosine (m6 A) is the most abundant mRNA chemical modification, and is modulated by m6 A‘writers’, ‘erasers’ and ‘readers’ proteins [1-3]. In vitro experiments suggest that m6 A regulates several aspects of RNA metabolism, including RNA decay, splicing and translation [1]. Recent genetic analyses in vivo showed that m6 A functions in sex determination in Drosophila [4,5], in maternal-to-zygotic transition and haematopoietic stem cell specification during zebrafish embryogenesis [6, 7], in mouse spermatogenesis [8-10], and in mouse brain development [11]. We recently discovered that lineage-specific deletion of the m6 A ‘writer’ enzyme METTL3 in CD4+ T cells (Mettl3f/f; CD4-Cre) led to disruption of naïve T cell homeostasis [12]. CD4+ regulatory T cells (Tregs) comprise a critical subset of effector T cells, which are involved in resolution of inflammation and immunosuppression in tumor microenvironments [13]. However, the potential roles of m6 A mRNA modification in Treg functions in vivo are unknown.
10.1038/cr.2018.7
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