Volume 28, No 4, Apr 2018

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 28 Issue 4, April 2018: 491-493

LETTERS TO THE EDITOR

CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA

Shi-Yuan Li ^1,2, Qiu-Xiang Cheng ³, Jia-Kun Liu ^1,2, Xiao-Qun Nie ^1,2,Guo-Ping Zhao ^1,4 and Jin Wang ¹

¹Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200032 Shanghai, China; ² University of Chinese Academy of Sciences, 100049 Beijing, China; ³Shanghai Tolo Biotechnology Company Limited, 200233 Shanghai, China and ⁴Department of Microbiology and Li KaShing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Shatin, New Territories, China Correspondence: Qiu-Xiang Cheng (qxcheng@tolobio.com) orJin Wang (wangj01@hotmail.com)

10.1038/s41422-018-0022-x

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