Volume 28, No 4, Apr 2018
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 28 Issue 4, April 2018: 391-392
RESEARCH HIGHLIGHTS
Tamoxifen and ERα36: Fertilizing the seeds of breast cancer metastasis
Monika L. Burness 1 and Max S. Wicha 1
1University of Michigan Comprehensive Cancer Center, Michigan Medicine, Ann Arbor, MI, USA.
Correspondence: Max S. Wicha (mwicha@umich.edu)
Hormonal therapies including tamoxifen have been a mainstay for the treatment of breast tumors that express the classical estrogen receptor ERα66. Wang et al. now report that tamoxifen may paradoxically stimulate ALDH-expressing breast cancer stem cells via activation of the ERα66 variant ERα36.
10.1038/s41422-018-0028-4
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