Volume 28, No 4, Apr 2018
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 28 Issue 4, April 2018: 389-390
RESEARCH HIGHLIGHTS
Ubiquitin-induced phase separation of p62/SQSTM1
Lina Herhaus 1 and Ivan Dikic 1,2
1 Institute of Biochemistry II, Goethe University School of Medicine, Theodor-Stern-Kai 7, Frankfurt am Main 60590, Germany and 2 Buchmann Institute for Molecular Life Sciences,
Goethe University Frankfurt, Riedberg Campus, Max-von-Laue-Straße 15, Frankfurt am Main 60438, Germany
Correspondence: Correspondence: Ivan Dikic (ivan.dikic@biochem2.de)
During the process of autophagy, cytoplasmic material is targeted by autophagic receptor proteins, which were thought to segregate the cargo by forming aggregates. Recent evidence suggests that cargo is actually concentrated and segregated into protein condensates by ubiquitin chain-induced phase separation of autophagy receptor p62.
doi:10.1038/s41422-018-0030-x
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