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Volume 28, No 6, Jun 2018

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 28 Issue 6, June 2018: 616-624

REVIEWS

Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism

Ying Yang 1,2,3 , Phillip J. Hsu 4,5 , Yu-Sheng Chen 1,2 and Yun-Gui Yang 1,2,3

1CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; 2University of Chinese Academy of Sciences, Beijing 100049, China; 3Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China; 4Department of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA and 5Medical Scientist Training Program/Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA
 Correspondence: Correspondence: Y.-G. Yang (ygyang@big.ac.cn)These authors contributed equally: Ying Yang, Phillip J. Hsu.

N6-methyladenosine (m6A) is a chemical modification present in multiple RNA species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and remove m6A have revealed its comprehensive roles in almost every aspect of mRNA metabolism, as well as in a variety of physiological processes. This review describes the current understanding of the m6A modification, particularly the functions of its writers, erasers, readers in RNA metabolism, with an emphasis on its role in regulating the isoform dosage of mRNAs.


https://doi.org/10.1038/s41422-018-0040-8

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