Volume 28, No 6, Jun 2018

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 28 Issue 6, June 2018: 607-608

RESEARCH HIGHLIGHTS

IMMP2L: a mitochondrial protease suppressing cellular senescence

Valentina Sica ^1,2,3,4 and Guido Kroemer ^1,2,3,4,5,6

¹Equipe 11 labelisée par la Ligue Nationale contre le Cancer, INSERM U1138, Centre de Recherche des Cordeliers, 75006 Paris, France; ²University of Paris Descartes, Sorbonne
Paris Cité, 75006 Paris, France; ³University of Pierre et Marie Curie, 75006 Paris, France; ⁴Metabolomics and Cell Biology Platforms, GRCC, 94805 Villejuif, France; ⁵Pôle de Biologie,Hôpital Européen Georges Pompidou, 75015 Paris, France and ⁶ Karolinska Institute, Department of Women’s and Children’s Health, Karolinska University Hospital, 17176
Stockholm, Sweden
Correspondence: Correspondence: Guido Kroemer (kroemer@orange.fr)

Cellular senescence contributes to organismal aging and tumor suppression. A recent paper by Yuan et al. published in Cell Research now unveils that switching off a mitochondrial protease can simultaneously suppress phospholipid biosynthesis and lethal signaling for senescence induction.

https://doi.org/10.1038/s41422-018-0051-5

FULL TEXT | PDF

Browse 1112