Volume 28, No 8, Aug 2018

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 28 Issue 8, August 2018: 783-784

RESEARCH HIGHLIGHTS

GPCR signaling: conformational activation of arrestins

Alem W. Kahsai1, Biswaranjan Pani ¹ and Robert J. Lefkowitz ^1,2,3

¹ Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA; ² Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA and ³ Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
Correspondence: Robert J. Lefkowitz (lefko001@receptor-biol.duke.edu)

The arrestins, a small family of versatile adapter proteins, play central roles in G-protein coupled receptor (GPCR) desensitization, endocytosis, and signal transduction. Two papers by Latorraca et al. and Eichel et al. published recently in Nature , dissect the independent and concerted mechanisms by which the phosphorylated GPCR tail and transmembrane core conformationally enable arrestins to perform their diverse functions.

https://doi.org/10.1038/s41422-018-0067-x

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