Volume 28, No 8, Aug 2018

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 28 Issue 8, August 2018: 785-786

RESEARCH HIGHLIGHTS

Competing for enhancers: PVT1 fine-tunes MYC expression

Abhijit Parolia ^1,2,3, Marcin Cieślik ^1,2 and Arul M. Chinnaiyan ^1,2,4,5,6

¹Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA; ²Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; ³Molecular and Cellular Pathology Program, University of Michigan, Ann Arbor, MI 48109, USA; ⁴Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109,
USA; ⁵Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA and ⁶Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
Correspondence: Correspondence: Arul M. Chinnaiyan (arul@umich.edu)

Cho and colleagues uncover a novel mechanism of transcriptional repression of MYC which attributes a tumor-suppressive role to the neighboring PVT1 promoter, and shed light on recurrent chromosomal rearrangements within the MYC locus.

https://doi.org/10.1038/s41422-018-0064-0

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