Volume 28, No 9, Sep 2018

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 28 Issue 9, September 2018: 877-878

RESEARCH HIGHLIGHTS

p53 REEPs to sow ER–mitochondrial contacts

Florian J. Bock ^1,2 and Stephen W. G. Tait ^1,2

¹ Cancer Research UK Beatson Institute, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK and ² Institute of Cancer Sciences, University of Glasgow,
Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
Correspondence: Florian J. Bock (Florian.Bock@glasgow.ac.uk) or Stephen W. G. Tait (stephen.tait@glasgow.ac.uk)

The intrinsic pathway of apoptosis requires mitochondrial outer membrane permeabilization, a process that can be facilitated by mitochondrial Ca2+ influx. In a recent paper published inCell Research, Zheng and colleagues now show that p53-mediated changes in ER morphology, specifically in response to DNA damage, contribute to the induction of apoptosis.

https://doi.org/10.1038/s41422-018-0073-z

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