Volume 28, No 9, Sep 2018
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 28 Issue 9, September 2018: 955-957
LETTERS TO THE EDITOR
m6A RNA modification controls autophagy through upregulating ULK1 protein abundance
Shouheng Jin 1, Xiya Zhang 1, Yanyan Miao 1, Puping Liang 1,Kaiyu Zhu 1, Yuanchu She 1, Yaoxing Wu 1, Di-Ao Liu 1, Junjiu Huang 1,Jian Ren 1 and Jun Cui 1
1 State Key Laboratory of Oncology in South China, Cancer Center, Collaborative Innovation Center for Cancer Medicine, School of Life Sciences, Sun Yat-sen University, 510060 Guangzhou, China
Correspondence: Jian Ren (renjian.sysu@gmail.com) or Jun Cui (cuij5@mail.sysu.edu.cn)These authors contributed equally: Shouheng Jin, Xiya Zhang,Yanyan Miao.
N6-methyladenosine (m6A) is the prominent dynamic mRNA modification, governed by methyltransferase complex (“writers”), demethylases (“erasers”) and RNA-binding proteins (‘readers’).1 m6A modification directs mRNAs to distinct fates by grouping them for differential processing, translation and decay in the processes such as cell differentiation, embryonic development and stress responses.1,2 Owing to a deeper understanding of this modification and the technological advance, functional characterizations of m6A in gene regulation have become a hot topic that warrants further dissection.3,4
https://doi.org/10.1038/s41422-018-
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