Volume 28, No 10, Oct 2018

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 28 Issue 10, October 2018: 967-968

RESEARCH HIGHLIGHTS

cGAS activation in phased droplets

Yongbo Liu ¹, Hua-Bing Li ¹ and Richard A. Flavell ^2,3

¹Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China; ²Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520-8055, USA and ³Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA
Correspondence: Correspondence: H-B. Li (huabing.li@shsmu.edu.cn) or Richard A. Flavell (richard.flavell@yale.edu)

Cyclic GMP-AMP synthase (cGAS) is activated by DNA through direct binding. Active cGAS catalyzes the production of cyclic GMP-AMP (cGAMP), and consequently activates the innate immune responses. However, the detailed biological processes are poorly understood. Du and Chen demonstrated in a recent paper published on Science that DNA binding to cGAS robustly induced the formation of liquid like droplets in which cGAS was activated.

https://doi.org/10.1038/s41422-018-0087-6

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