Volume 28, No 11, Nov 2018

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 28 Issue 11, November 2018: 1046-1047

RESEARCH HIGHLIGHTS

Mitochondrial DNA synthesis fuels NLRP3 inflammasome

Rebecca C. Coll ¹, Caroline L. Holley ¹ and Kate Schroder ¹

¹Institute for Molecular Bioscience and IMB Centre for Inflammation and Disease Research, The University of Queensland, St Lucia, QLD, Australia
Correspondence: Correspondence: Rebecca C. Coll (r.coll@imb.uq.edu.au) or Kate Schroder (k.schroder@imb.uq.edu.au)

Mitochondria-derived signals are associated with NLRP3 inflammasome activation. A recent study in Nature by Zhong et al. shows that inflammasome priming drives new mitochondrial DNA synthesis, and proposes this to be a prerequisite for NLRP3 inflammasome signaling.

https://doi.org/10.1038/s41422-018-0093-8

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