Volume 28, No 12, Dec 2018

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 28 Issue 12, December 2018: 1125-1126

RESEARCH HIGHLIGHTS

ALPK1: innate attraction to the sweetness of bacteria

Yansong Xue ¹ and Si Ming Man ¹

¹Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia Correspondence: Correspondence: Si Ming. Man (siming.man@anu.edu.au)

Pattern-recognition receptors (PRRs) have critical roles in mediating the recognition of microbial and danger signals. A recent study by Zhou et al. published in Nature demonstrates that ALPK1 is a cytosolic PRR, which recognizes the bacterial metabolite ADP-Hep, triggering activation of the inflammatory NF-κB signaling pathway.

https://doi.org/10.1038/s41422-018-0100-0

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