Volume 28, No 12, Dec 2018

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 28 Issue 12, December 2018: 1127-1128

RESEARCH HIGHLIGHTS

New roles for RAD52 in DNA repair

Chaoyou Xue ¹ and Eric C. Greene ¹

¹Department of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10032, USA
Correspondence: Correspondence: Eric C. Greene (ecg2108@cumc.columbia.edu)

Transcriptionally active genetic loci can be subject to the formation of DNA double strand breaks (DSBs) that arise due to the formation of R-loops. In a recent study published in Cell, Yasuhara and colleagues have revealed a remarkable new mechanism that allows cells to channel DSBs within active genes through a new repair pathway called transcription-associated homologous recombination repair.

https://doi.org/10.1038/s41422-018-0105-8

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