Volume 29, No 1, Jan 2019
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 29 Issue 1, January 2019: 87-89 | Open Access
LETTERS TO THE EDITOR
A single circular chromosome yeast
Yangyang Shao 1,2, Ning Lu 1,2, Chen Cai 2,3,4, Fan Zhou 5, Shanshan Wang 3, Zhihu Zhao 6, Guoping Zhao 1,7,8,9, Jin-Qiu Zhou 3,4, Xiaoli Xue 1 and Zhongjun Qin 1
1 Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032 Shanghai, China;
2 University of Chinese Academy of Sciences, 100049 Beijing, China;
3 The State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 200031
Shanghai, China;
4 School of Life Science and Technology,
ShanghaiTech University, 201210 Shanghai, China;
5 Wuhan Frasergen Bioinformatics Co, 430075 Wuhan, China;
6 Beijing Institute of Biotechnology, 100071 Beijing, China;
7 Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, 201203 Shanghai, China;
8 Department of Microbiology and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales
Hospital, Shatin, New Territories, Hong Kong SAR, China and
9 State Key Laboratory of Genetic Engineering, Department of Microbiology, School of Life Sciences and Institute of Biomedical Sciences, Fudan University, 200032 Shanghai, China
These authors contributed equally: Yangyang Shao, Ning Lu, Chen Cai, Fan Zhou
Correspondence: Zhihu Zhao (zhaozh@bmi.ac.cn) or Guoping Zhao (gpzhao@sibs.ac.cn) or Jin-Qiu Zhou (jqzhou@sibcb.ac.cn) or Xiaoli Xue (xlxue@sibs.ac.cn) or Zhongjun Qin
Dear editor,
Most of the prokaryotic cells contain a single circular chromosome.
In contrast, the eukaryotic cells usually contain multiple
linear chromosomes. Recently, we artificially created a single linear
chromosome yeast strain SY14 from native 16 chromosomes in a
haploid Saccharomyces cerevisiae, which displays minor fitness
defects.1 In this study, we have created a new yeast strain which
contains a single circular chromosome and apparently has not
been found in nature.
https://doi.org/10.1038/s41422-018-0110-y
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