Volume 29, No 3, Mar 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 3, March 2019: 177-178

RESEARCH HIGHLIGHTS

Antiviral immunity: a link to bile acids

Jing Wang ^1,2, Richard A. Flavel ^{l 2,3,4} and Hua-Bing Li ^1,2

¹Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, Shanghai Jiao Tong University School of Medicine,200025 Shanghai, China; ²Yale Center for ImmunoMetabolism, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China; ³Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8055, USA and ⁴Howard Hughes Medical Institute, Yale University, New Haven, CT 06520-8055, USA
Correspondence: Richard A. Flavell (richard.flavell@yale.edu) or Hua-Bing Li (huabing.li@shsmu.edu.cn)

A recent study in Cell Research by Hu et al. describes a novel function of intracellular bile acids (BAs), a class of cholesterol-derived metabolites, which activate several key innate antiviral signaling components through the TGR5-β-arrestin-SRC pathway to potentiate antiviral immunity. This finding adds a new metabolic regulatory dimension of innate antiviral response and provides a new antiviral strategy by supplementing BAs.

https://doi.org/10.1038/s41422-019-0148-5

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