Volume 29, No 3, Mar 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 3, March 2019: 179-180

RESEARCH HIGHLIGHTS

Degrading proteins in animals: “PROTAC”tion goes in vivo

Jianping Guo ^1,2, Jing Liu ^2,3 and Wenyi Wei ²

¹The First Affiliated Hospital, Sun Yat-sen University, 510275 Guangzhou, Guangdong, China; ²Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA and ³Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Frontier Institute of Science and Technology, Xi’an Jiaotong University, 710049 Xi’ an, Shanxi, China
Correspondence: Wenyi Wei (wwei2@bidmc.harvard.edu)These authors contributed equally: Jianping Guo, Jing Liu

In a recent paper published in Cell Discovery , Sun et al. report a novel chemical approach to rapidly and reversibly deplete endogenous proteins globally in both small and large animals via the PROTAC (PROteolysis TArgeting Chimera) approach. This strategy not only provides a powerful tool for protein function studies in vivo, but also highlights the potential of using PROTAC in future human cancer therapies.

https://doi.org/10.1038/s41422-019-0144-9

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