Volume 29, No 3, Mar 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 3, March 2019: 181-182

RESEARCH HIGHLIGHTS

Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network

Kaiwen W. Chen ¹ , Dave Boucher ¹ and Petr Broz ¹

¹Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland
These authors contributed equally: Kaiwen W. Chen, Dave Boucher Correspondence: Petr Broz (petr.broz@unil.ch)

The NLRP3 inflammasome detects a variety of pathogen-derived and host-derived signals, but its mechanism of activation has long remained uncharacterized. In a recent study in Nature, Chen et al. demonstrate that NLRP3 activators induce the disassembly of the trans-Golgi network (TGN) and that NLRP3 is targeted for activation at the dispersed TGN (dTGN) by ionic bonding between its conserved polybasic region and phosphatidylinositol-4-phosphates on the dTGN.

https://doi.org/10.1038/s41422-018-0138-z

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