Volume 29, No 4, Apr 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 4, April 2019: 259-260

RESEARCH HIGHLIGHTS

STIM1 is a precise thermo-sensor in skin

Robert M. Nwokonko¹, Yandong Zhou¹ and Donald L. Gill ¹

¹ Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, PA 17033, USA
Correspondence: Yandong Zhou (zhouyd@psu.ed) or Donald L. Gill (dongill@psu.edu)

The Ca 2+ sensor, STIM1, couples to activate Orai Ca 2+ channels in response to endoplasmic reticulum Ca 2+ depletion. New in vivo targeting approaches reveal that STIM1 mediates precise temperature sensing in skin through heat-induced regulation of Orai channels.

https://doi.org/10.1038/s41422-019-0154-7

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