Volume 29, No 4, Apr 2019
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 29 Issue 4, April 2019: 263-264
RESEARCH HIGHLIGHTS
Broken hearts: Iron overload, ferroptosis and cardiomyopathy
Marcus Conrad 1 and Bettina Proneth 1
1Helmholtz Zentrum München, Institute of Developmental Genetics, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany
Correspondence: Marcus Conrad (marcus.conrad@helmholtz-muenchen.de)
In a recently published paper in Proc Natl Acad Sci USA, Fang et al. elegantly demonstrated that doxorubicin treatment or transient ischemia/reperfusion in mice triggers ferroptosis, a distinctive form of necrotic cell death marked by iron-dependent lipid peroxidation, which is the main underlying mechanism in the pathogenesis of cardiomyopathy.
https://doi.org/10.1038/s41422-019-0150-y
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