Volume 29, No 5, May 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 5, May 2019: 339-340

RESEARCH HIGHLIGHTS

In vivo ways to unveil off-targets

Guigen Zhang¹ , Zhuo Zhou¹ and Wensheng Wei ¹

¹ Biomedical Pioneering Innovation Center, Beijing Advanced Innovation Center for Genomics, Peking-Tsinghua Center for Life Sciences, Peking University Genome Editing Research Center, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, 100871 Beijing, China
Correspondence: Wensheng Wei (wswei@pku.edu.cn)

Base editors enable single nucleotide conversion without causing unwanted indels. Two recent studies reveal that cytosine base editors (CBEs), but not adenine base editors (ABEs), induce unexpected genome-wide off-target mutations, calling for high-fidelity CBEs.

https://doi.org/10.1038/s41422-019-0159-2

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