Volume 29, No 6, Jun 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 6, June 2019: 425-426

RESEARCH HIGHLIGHTS

AMPK hierarchy: a matter of space and time

David Carling ¹

¹ Division of Clinical Sciences, MRC London Institute of Medical Sciences, Imperial College, Hammersmith Hospital Campus, DuCane Road, London W12 0NN, UK
Correspondence: David Carling (dcarling@imperial.ac.uk)

AMP-activated protein kinase (AMPK) is a key sensor of energy balance in eukaryotic cells, responding to low energy status by switching off anabolic pathways and upregulating catabolic processes. Zong and colleagues now show that different intensities of stimulation trigger activation of specific subcellular pools of AMPK, resulting in phosphorylation of different downstream targets.

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