Volume 29, No 6, Jun 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 6, June 2019: 429-431

RESEARCH HIGHLIGHTS

LKB1 restrains dendritic cell function

Stefanie K. Wculek¹ and David Sancho ¹

¹ Immunobiology laboratory, Fundación Centro Nacional de Investigaciones Cardiovasculares “Carlos III” (CNIC), Madrid, Spain
Correspondence: David Sancho (dsancho@cnic.es)

Three independent recent studies support the notion that liver kinase B1 (LKB1), a key nutrient sensor, controls dendritic cell (DC) function. Selective loss of LKB1 in DCs leads to their increased ability to prime effector T cell responses, but the prevailing effect is the expansion of thymus-derived natural regulatory T cells, creating a dominant immunosuppressive environment.

https://doi.org/10.1038/s41422-019-0169-0

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