Volume 29, No 6, Jun 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 6, June 2019: 502-505

LETTERS TO THE EDITOR

Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis

Zhiqiang Wu¹, Linjun Weng¹, Tengbo Zhang¹, Hongling Tian¹,Lan Fang¹, Hongqi Teng¹, Wen Zhang¹, Jing Gao², Yun Hao¹,Yaxu Li¹, Hu Zhou ² and Ping Wang¹

¹Tongji University Cancer Center, Shanghai Tenth People’s Hospital of Tongji University, School of Medicine, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China and ²Department of Analytical Chemistry and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese, Academy of Sciences, Shanghai 201203, China.
These authors contributed equally: Zhiqiang Wu, Linjun Weng,
Tengbo Zhang.
Correspondence:

Dear Editor,

Cancer cells often upregulate the expression of ligands for the inhibitory immune checkpoints receptor to escape anti-tumor immunity1. Targeting inhibitory immune checkpoints has become one of the most promising anticancer therapeutic inventions. Infiltration of myeloid cells, especially phagocytic cells, to tumors is often associated with chemotherapy resistance and progression of various cancer types. Phagocytosis of cancer cells is the major mechanism for these myeloid cells-mediated antitumor activity. However, many types of cancer cells express high level of ‘don’t eat me’ signals on the cell surface to escape the phagocytic cells-mediated antitumor immunity.

https://doi.org/10.1038/s41422-019-0177-0

FULL TEXT | PDF

Browse 1015