Volume 29, No 7, Jul 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 7, July 2019: 507-508

RESEARCH HIGHLIGHTS

UIM-UDS: a new interface between ATG8 and its interactors

Yuchen Lei¹ and Daniel J. Klionsky ¹

¹Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
Correspondence: Daniel J. Klionsky (klionsky@umich.ed

The autophagy-related protein ATG8 (mammalian LC3) plays a key role in cargo recognition during selective macroautophagy/autophagy. The ubiquitin-interacting motif (UIM)-UIM-docking site (UDS) was recently identified as a new interface between ATG8 and its interactors, which expands the list of autophagy receptors and adaptors, and also suggests an additional avenue for potential therapeutic designs for the treatment of human diseases.

https://doi.org/10.1038/s41422-019-0179-y

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