Volume 29, No 7, Jul 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 7, July 2019: 509-511

RESEARCH HIGHLIGHTS

The insulin receptor goes nuclear

Thiago M. Batista¹, Carly T. Cederquist¹ and C. Ronald Kahn¹

¹ Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Brigham and Women’s Hospital Department of Internal Medicine, Harvard Medical School, Boston, MA
02215, USA
Correspondence: C. Ronald Kahn (c.ronald.kahn@joslin.harvard.edu)

Regulation of gene expression is a major component of insulin action, which is classically thought to occur via phosphorylation, relocalization and/or processing of transcriptional regulators downstream of the insulin receptor (IR) signaling cascade. A recent study in Cell suggests a mechanism by which IR itself translocates to the nucleus and forms transcriptional complexes with RNA polymerase II, host cell factor-1 and transcription factors to directly regulate gene expression, thus adding a new complementary pathway to control this important set of insulin actions.

https://doi.org/10.1038/s41422-019-0185-0

FULL TEXT | PDF

Browse 908