Volume 29, No 7, Jul 2019
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 29 Issue 7, July 2019: 509-511
RESEARCH HIGHLIGHTS
The insulin receptor goes nuclear
Thiago M. Batista1, Carly T. Cederquist1 and C. Ronald Kahn1
1 Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Brigham and Women’s Hospital Department of Internal Medicine, Harvard Medical School, Boston, MA
02215, USA
Correspondence: C. Ronald Kahn (c.ronald.kahn@joslin.harvard.edu)
Regulation of gene expression is a major component of insulin action, which is classically thought to occur via phosphorylation, relocalization and/or processing of transcriptional regulators downstream of the insulin receptor (IR) signaling cascade. A recent study in Cell suggests a mechanism by which IR itself translocates to the nucleus and forms transcriptional complexes with RNA polymerase II, host cell factor-1 and transcription factors to directly regulate gene expression, thus adding a new complementary pathway to control this important set of insulin actions.
https://doi.org/10.1038/s41422-019-0185-0
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