Volume 29, No 7, Jul 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 7, July 2019: 512-513

RESEARCH HIGHLIGHTS

RNA binding to p62 impacts selective autophagy

Mohit Misra ^1,2 and Ivan Dikic ^1,2

¹Institute of Biochemistry II, Goethe University - Medical Faculty, University Hospital Frankfurt, Theodor-Stern-Kai 7, Frankfurt am Main 60590, Germany and ²Buchmann Institute
for Molecular Life Sciences, Goethe University Frankfurt, Riedberg Campus, Max-von-Laue-Straße 15, Frankfurt am Main 60438, Germany
Correspondence: Ivan Dikic (ivan.dikic@biochem2.de)

Role of RNA regulation in autophagy was rather unexplored until Horos et al. recently showed that vault RNA1-1 binds directly to p62/SQSTM1, a well-established autophagy receptor. This binding leads to inhibition of p62 oligomerization and negative regulation of selective autophagy pathways.

https://doi.org/10.1038/s41422-019-0167-2

FULL TEXT | PDF

Browse 909