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Volume 29, No 7, Jul 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 7, July 2019: 592-595

LETTERS TO THE EDITOR

Canine transmissible venereal tumor genome reveals ancient introgression from coyotes to pre-contact dogs in North America

Xuan Wang1 , Bo-Wen Zhou 1,2, Melinda A. Yang3, Ting-Ting Yin 1,Fang-Liang Chen4, Sheila C. Ommeh 5, Ali Esmailizadeh6,Melissa M. Turner7, Andrei D. Poyarkov8, Peter Savolainen9,Guo-Dong Wang 1,2,10 , Qiaomei Fu 3,11 and Ya-Ping Zhang 1,2,10

1State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223 Yunnan, China; 2Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650223 Yunnan, China; 3Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, IVPP, Chinese Academy of Sciences, 100044 Beijing, China; 4Kunming Police Dog Base of the Ministry of Public Security, Kunming 650204 Yunnan, China; 5Animal Biotechnology Group, Institute of Biotechnology Research, Jomo Kenyatta University of Agriculture and Technology, Nairobi 00200, Kenya; 6Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman PB 76169-133, Iran; 7Department of Forestry and Environmental Resources, Fisheries, Wildlife, and Conservation Biology Program, North Carolina State University, Raleigh, NC 27695,USA; 8Severtsov Institute of Ecology and Evolution, Russian Academy of Science, Leninskiy Prospect, 33, Moscow, Russia119071; 9Department of Gene Technology, KTH-Royal Institute of Technology, Science for Life Laboratory, Tomtebodavägen 23A, 17165 Solna, Sweden; 10 Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223 Yunnan, China and 11 Center for Excellence in Life and Paleoenvironment, Chinese Academy of Sciences, 100044 Beijing, China
These authors contributed equally: Xuan Wang, Bo-Wen Zhou,
Melinda A. Yang.
 Correspondence: Guo-Dong Wang (wanggd@mail.kiz.ac.cn) orQiaomei Fu (fuqiaomei@ivpp.ac.cn) or YaPing Zhang (zhangyp@mail.kiz.ac.cn)

Dear Editor,

Canine transmissible venereal tumor (CTVT), the oldest known somatic cell line, is a living fossil of the original founder, transmitted from host’s cancer cells to other canids during the mating process.1 Since it was shown ten years ago that living cells from an ancient host could be transmitted among canids, the origin of CTVT has been studied continuously.2 Recent comparison of the CTVT genetic data with a more comprehensive canine reference panel including pre-contact dogs (PCDs) from North America argued that the CTVT founder (the original canid infected with CTVT) is the closest detectable lineage to PCDs, and that this clade underwent introgression from wild canids in North America.3


https://doi.org/10.1038/s41422-019-0183-2

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