Volume 29, No 8, Aug 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 8, August 2019: 603-604

RESEARCH HIGHLIGHTS

Microbiota guides insulin trafficking in beta cells

Ozren Stojanović ^1,2 and Mirko Trajkovski ^1,2,3

¹ Department of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire, University of Geneva, 1211 Geneva, Switzerland; ²Diabetes Centre, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland and ³Institute of Genetics and Genomics in Geneva (IGE3), University of Geneva, 1211 Geneva, Switzerland
Correspondence: Mirko Trajkovski (Mirko.Trajkovski@unige.ch)

Pancreatic beta cells produce insulin on intricate cellular assembly line, but the extent of the gut microbiota involvement was not clear. It emerges that fragments of bacterial cell wall released by lysozyme 1 in the intestinal lumen are necessary to keep the machinery running, acting on the cytosolic peptidoglycan receptor Nod1 in the beta cells to regulate the insulin trafficking and glucose tolerance.

https://doi.org/10.1038/s41422-019-0200-5

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