Volume 29, No 8, Aug 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 8, August 2019: 605-606

RESEARCH HIGHLIGHTS

Crystallizing BubR1’s kinase activity

Jazeel F. Limzerwala¹ and Jan M. van Deursen ^1,2

¹ Departments of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA and ²Departments of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
Correspondence: Jan M. van Deursen (vandeursen.jan@mayo.edu)

BubR1 has been implicated in fundamental biological processes such as cell division, cancer, aging and age-related diseases, but whether this mitotic checkpoint protein acts as a kinase has remained a matter of intense debate. With a multi-pronged approach involving the use of structural biology, substrate identification, pharmacological inhibition of kinase activity, and functional assays, Huang et al. now provide compelling evidence that BubR1 has enzymatic activity.

https://doi.org/10.1038/s41422-019-0199-7

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