Volume 29, No 9, Sep 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 9, September 2019: 687-689

RESEARCH HIGHLIGHTS

Towards precise, safe genome editing

Sebastian Memczak ^1,2, Yanjiao Shao ^1,3 and Juan Carlos Izpisua Belmonte ¹

¹ Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; ²Paul F. Glenn Center for Biology of Aging Research at the Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA and ³Universidad Católica San Antonio de Murcia (UCAM), Campus de los Jeronimos N135,12 Guadalupe, CA 30107, Spain
Correspondence: Juan Carlos Izpisua Belmonte (belmonte@salk.edu)

Commonly used Cas9:gRNA programmed base-editor complexes introduce frequent, so far unrecognized RNA off-target edits. Novel, engineered enzymes may overcome this hurdle towards clinical applications of genome engineering.

https://doi.org/10.1038/s41422-019-0188-x

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