Volume 29, No 9, Sep 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 9, September 2019: 690-691

RESEARCH HIGHLIGHTS

Lnc(ing) interferon production and action

Ganes C. Sen¹ and Bryan R. G. Williams ^1,2

¹ Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA and ²Hudson Institute of Medical Research and Department of Molecular and Translational Science, Monash University, Clayton, Australia Correspondence: Ganes C. Sen (seng@ccf.org)

Host-virus homeostasis is intricately regulated at multiple steps of both interferon (IFN) induction and IFN action; a recent paper by Zhou et al. has revealed a new feature of this complex regulation. They report the discovery of an IFN-inducible cytoplasmic long non-coding RNA, lncLrrc55-AS, which promotes IRF3 phosphorylation by inactivating the phosphatase PP2A, thus providing a positive feedback loop to IFN induction.

https://doi.org/10.1038/s41422-019-0207-y

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