Volume 29, No 9, Sep 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 9, September 2019: 694-695

RESEARCH HIGHLIGHTS

Histone lysine de-β-hydroxybutyrylation by SIRT3

Susan M. Abmayr ^1,2 and Jerry L. Workman 1

¹The Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA and ²Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
Correspondence: Jerry L. Workman (JLW@stowers.org)

Recent studies have demonstrated the addition and removal of a smorgasbord of site-specific acylation modifications on lysine residues of histone tails. The study by Zhang et al. now shows how the SIRT3 histone deacylase exhibits class specificity, acting on only a subset of β-hydroxybutyrylated lysines.

https://doi.org/10.1038/s41422-019-0211-2

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