Volume 29, No 10, Oct 2019
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 29 Issue 10, October 2019: 779-780
RESEARCH HIGHLIGHTS
The microbiome: A target for Alzheimer disease?
Dong-oh Seo1, Benjamin D. Boros1 and David M. Holtzman1
1Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110,
USA
Correspondence: David M. Holtzman (holtzman@wustl.edu)
Although recent accumulating data have suggested that gut microbiota associates with Alzheimer disease (AD) pathogenesis, it is not yet clear how alterations in the gut microbiota mechanistically contribute to different aspects of AD pathology. Here, Wang et al. identified that infiltrating peripheral immune cells facilitated by gut microbiota imbalance in mouse models of amyloidosis are associated with changes in behavior and AD-related pathology.
https://doi.org/10.1038/s41422-019-0227-7
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