Advanced Search

Submit Manuscript

Volume 29, No 11, Nov 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 11, November 2019: 879-880

RESEARCH HIGHLIGHTS

hnRNPA2B1: a nuclear DNA sensor in antiviral immunity

Xingli Zhang 1,2 , Richard A. Flavell 2,3,4 and Hua-Bing Li 1,2

1Shanghai Institute of Immunology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2Shanghai Jiao Tong University School of Medicine - Yale Institute for Immune Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 3Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8055, USA and 4Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520-8055, USA
 Correspondence: Richard A. Flavell (richard.flavell@yale.edu) or Hua-Bing Li (huabing.li@shsmu.edu.cn)

Pattern recognition receptors (PRRs) have critical roles in mediating innate immune responses. In a recent study published in Science , Cao and colleagues identified hnRNPA2B1 as a new nuclear DNA sensor that initiated type I interferon (IFN-I) production upon DNA virus infection and amplified IFN-I responses by directly enhancing STING-dependent cytosolic DNA sensing pathways.


https://doi.org/10.1038/s41422-019-0226-8

FULL TEXT | PDF

Browse 624