Volume 29, No 11, Nov 2019
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 29 Issue 11, November 2019: 956-959
LETTERS TO THE EDITOR
Precise temporal regulation of Dux is important for embryo development
Mingyue Guo 1, Yanping Zhang1, Jianfeng Zhou1, Yan Bi1,Junqin Xu1, Ce Xu1, Xiaochen Kou1, Yanhong Zhao1, Yanhe Li1,Zhifen Tu1, Kuisheng Liu1, Jiaming Lin1, Peng Yang1, Shaorong Gao 1 and Yixuan Wang 1
1 Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, China
These authors contributed equally: Mingyue Guo, Yanping Zhang
Correspondence: Peng Yang (peng.yang@tongji.edu.cn) orShaorong Gao (gaoshaorong@tongji.edu.cn) orYixuan Wang (wangyixuan@tongji.edu.cn)
Dear Editor,
Zygotic genome activation (ZGA) following fertilization is accomplished through a process termed the maternal-to-zygotic transition, during which the maternal RNAs and proteins are degraded and zygotic genome is transcriptionally activated.1 In mice, minor ZGA occurs from S phase of the zygote to G1 phase of the two-cell (2C) embryo, while major ZGA takes place during the middle-to-late 2C stage with a burst of transcription of totipotent cleavage stage-specific genes and retrotransposons.2 Dux has been recently identified and considered as a master inducer that regulates the ZGA process.3,4,5 Dux can directly bind and robustly activate 2C stage-specific ZGA transcripts and convert mouse embryonic stem cells (mESCs) to a 2C-like state with unique features that resembles the 2C embryos.4 Intriguingly, ~20% embryos with zygotic depletion of Dux unexpectedly reached morula or blastocyst stage even though defective ZGA program was detected.3
https://doi.org/10.1038/s41422-019-0238-4
FULL TEXT | PDF
Browse 1046
