Volume 29, No 12, Dec 2019

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 29 Issue 12, December 2019: 969-970

RESEARCH HIGHLIGHTS

DDX3X: stressing the NLRP3 inflammasome

Daniel Fox ¹ and Si Ming Man ¹

¹Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra 2601 ACT, Australia
Correspondence: Si Ming Man (siming.man@anu.edu.au)

Stress granules and inflammasomes are intracellular complexes that assemble in response to cellular stress signals, enabling cells to persist and perish, respectively. In a recent study published in Nature, Samir et al. identify the helicase DDX3X as a central decision maker in the formation of pro-survival stress granules or pro-death NLRP3 inflammasomes.

https://doi.org/10.1038/s41422-019-0250-8

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