Volume 30, No 1, Jan 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 1, January 2020: 1-2

RESEARCH HIGHLIGHTS

Cleaning up stalled ribosome-translocon complexes with ufmylation

Adele Xu¹ and Maria Barna ^1,2

¹Department of Genetics, Stanford University, Stanford, CA 94305, USA and ²Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
Correspondence: Maria Barna (mbarna@stanford.edu)

Ufmylation, a metazoan-specific ubiquitin-like post-translational modification, is implicated in numerous cellular processes and mammalian phenotypes. Here, Wang et al. uncover an important function of ribosome ufmylation in protein quality control at ribosomes that have stalled during co-translational translocation of endoplasmic reticulum (ER)-targeted proteins.

https://doi.org/10.1038/s41422-019-0249-1

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