Volume 30, No 1, Jan 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 1, January 2020: 3-4

RESEARCH HIGHLIGHTS

A new checkpoint against ferroptosis

Deguang Liang¹, Liang Deng² and Xuejun Jiang¹

¹Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA and ²Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Correspondence: Liang Deng (dengl@mskcc.org) or Xuejun Jiang (jiangx@mskcc.org)

By taking different approaches, two research groups made the same discovery that a CoQ oxidoreductase (renamed as ferroptosis suppressor protein-1, or FSP1) can inhibit ferroptosis, a form of cell death driven by iron-dependent phospholipid peroxidation. As FSP1 is expressed in various cancers and can halt ferroptosis even in the absence of glutathione peroxidase 4 (GPX4), which was previously considered indispensable for ferroptosis surveillance, the potential of FSP1 as a new cancer therapeutic target should be explored.

https://doi.org/10.1038/s41422-019-0258-0

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