Volume 30, No 1, Jan 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 1, January 2020: 95-97   |  Open Access

LETTERS TO THE EDITOR

Hepatic spheroids derived from human induced pluripotent stem cells in bio-artificial liver rescue porcine acute liver failure

Sitong Chen¹, Jinglin Wang², Haozhen Ren², Yinan Liu¹,Chengang Xiang¹, Cheng Li³, Shichun Lu⁴, Yan Shi¹,Hongkui Deng¹ and Xiaolei Shi²

¹ Department of Cell Biology, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center and the MOE Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, PekingTsinghua Center for Life Sciences, Peking University, Beijing 100191, China; ² Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Hepatobiliary Institute of Nanjing University, Nanjing, Jiangsu, China; ³Center for Bioinformatics, Peking University, Beijing 100871, China and ⁴Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China
These authors contributed equally: Sitong Chen, Jinglin Wang,
Haozhen Ren
Correspondence: Yan Shi (shiyan@bjmu.edu.cn) orHongkui Deng (hongkui_deng@pku.edu.cn) or Xiaolei Shi (njsxl2000@163.com)

Dear Editor,

Acute liver failure (ALF) is a complicated disorder showing a nearly 80% mortality rate, and there is currently no effective medical solutions for ALF except liver transplantation.1 Bio-artificial liver (BAL) system is a device that consists of a bioreactor filled with hepatocytes, which could potentially rescue ALF patients by providing partial liver function until a suitable donor liver can be found or the native liver has self-regenerated.2,3

https://doi.org/10.1038/s41422-019-0261-5

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