Volume 30, No 2, Feb 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 2, February 2020: 101-102

RESEARCH HIGHLIGHTS

Transferrin: a blood coagulation modifier

Alvin H. Schmaier ¹

¹ Division of Hematology and Oncology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
Correspondence: Alvin H. Schmaier (ahs21@case.edu)

The proteins of the mammalian blood coagulation system, a group of proteins and regulators whose major job is to stop bleeding, exist in the plasma vascular compartment and have opportunity to interact with multiple other proteins. The article by Tang et al. presents the novel observation that transferrin, an iron transport protein that exists in plasma in concentration excess to all the blood coagulation proteins, promotes blood coagulation by increasing thrombin and factor XIIa activities and inhibiting antithrombin.

https://doi.org/10.1038/s41422-020-0275-z

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