Volume 30, No 2, Feb 2020
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 30 Issue 2, February 2020: 105-118
ORIGINAL ARTICLES
A novel pathway regulates social hierarchy via lncRNA AtLAS and postsynaptic synapsin IIb
Mei Ma 1, Wan Xiong1, Fan Hu1, Man-Fei Deng1, Xian Huang 1, Jian-Guo Chen2, Heng-Ye Man3, Youming Lu 2, Dan Liu 1,2 and Ling-Qiang Zhu 1,2
1Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; 2The Institute of Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China and 3Department of Biology, Boston University, Boston, MA 02215, USA
Correspondence: Dan Liu (liudan_echo@mail.hust.edu.cn) or Ling-Qiang Zhu (zhulq@mail.hust.edu.cn)
Dominance hierarchy is a fundamental phenomenon in grouped animals and human beings, however, the underlying regulatory mechanisms remain elusive. Here, we report that an antisense long non-coding RNA (lncRNA) of synapsin II, named as AtLAS, plays a crucial role in the regulation of social hierarchy. AtLAS is decreased in the prefrontal cortical excitatory pyramidal neurons of dominant mice; consistently, silencing or overexpression of AtLAS increases or decreases the social rank, respectively. Mechanistically, we show that AtLAS regulates alternative polyadenylation of synapsin II gene and increases synapsin 2b (syn2b) expression. Syn2b reduces AMPA receptor (AMPAR)-mediated excitatory synaptic transmission through a direct binding with AMPAR at the postsynaptic site via its unique C-terminal sequence. Moreover, a peptide disrupting the binding of syn2b with AMPARs enhances the synaptic strength and social ranks. These findings reveal a novel role for lncRNA AtLAS and its target syn2b in the regulation of social behaviors by controlling postsynaptic AMPAR trafficking.
https://doi.org/10.1038/s41422-020-0273-1
FULL TEXT | PDF
Browse 846
