Volume 30, No 3, Mar 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 3, March 2020: 195-196

RESEARCH HIGHLIGHTS

Make or break: the ribosome as a regulator of mRNA decay

Anthony J. Veltri¹, Karole N. D’Orazio¹ and Rachel Green ¹

¹ Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, USA
Correspondence: Rachel Green (ragreen@jhmi.edu)

Cells regulate α- and β-tubulin levels through a negative feedback loop which degrades tubulin mRNA upon detection of excess free tubulin protein. In a recent study in Science , Lin et al. discover a role for a novel factor, TTC5, in recognizing the N-terminal motif of tubulins as they emerge from the ribosome and in signaling co-translational mRNA decay.

https://doi.org/10.1038/s41422-019-0271-3

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