Volume 30, No 4, Apr 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 4, April 2020: 279-280

RESEARCH HIGHLIGHTS

Gut nociceptors: sentinels promoting host defense

Stuart M. Brierley ^1,2,3

¹Visceral Pain Research Group, College of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia; ²Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, SA 5000, Australia and ³Discipline of Medicine, University of Adelaide,
Adelaide, SA 5000, Australia
Correspondence: Stuart M. Brierley (stuart.brierley@flinders.edu.au)

Gut-innervating nociceptive neurons detect noxious mechanical and chemical stimuli within our gut, constituting the start of the ‘gut pain’ pathway. In a recent paper in Cell, Lai et al. report that these nociceptors also play major roles in sensing intestinal bacterial pathogens as well as defending the host by limiting pathogen colonization and invasion.

Cell Research (2006) 16:742-749. doi: 10.1038/sj.cr.7310090; published online 29 Aug 2006

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