Volume 30, No 4, Apr 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 4, April 2020: 281-282

RESEARCH HIGHLIGHTS

RNA helicases regulate RNA condensates

Xiang-Dong Fu ¹

¹Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA
Correspondence: Xiang-Dong Fu (xdfu@ucsd.edu)

Stress granules are cytoplasmic membraneless RNA condensates for storing non-translating mRNAs, which are induced in response to various forms of stress. In a recent issue of Cell , Tauber et al. show that RNA helicases, particularly eIF4A, act to limit the recruitment of non-translating mRNAs to stress granules by disrupting RNA-RNA interactions, which provides a prototype for regulated phase separation in RNA condensates.

Cell Research advance online publication 6 Jun 2006; doi: 10.1038/sj.cr.7310067

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