Volume 30, No 4, Apr 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 4, April 2020: 328-342   |  Open Access

REVIEW ARTICLE

Signaling networks in immunometabolism

Jordy Saravia¹ , Jana L. Raynor , Nicole M. Chapman , Seon Ah Lim , Hongbo Chi^,*

¹Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
These authors contributed equally: Jordy Saravia, Jana L. Raynor, Nicole M. Chapman Correspondence: Hongbo Chi(hongbo.chi@stjude.org)

Adaptive immunity is essential for pathogen and tumor eradication, but may also trigger uncontrolled or pathological inflammation. T cell receptor, co-stimulatory and cytokine signals coordinately dictate specific signaling networks that trigger the activation and functional programming of T cells. In addition, cellular metabolism promotes T cell responses and is dynamically regulated through the interplay of serine/threonine kinases, immunological cues and nutrient signaling networks. In this review, we summarize the upstream regulators and signaling effectors of key serine/threonine kinase-mediated signaling networks, including PI3K–AGC kinases, mTOR and LKB1–AMPK pathways that regulate metabolism, especially in T cells. We also provide our perspectives about the pending questions and clinical applicability of immunometabolic signaling. Understanding the regulators and effectors of immunometabolic signaling networks may uncover therapeutic targets to modulate metabolic programming and T cell responses in human disease.

https://doi.org/10.1038/s41422-020-0301-1

FULL TEXT | PDF

Browse 792