Volume 30, No 5, May 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 5, May 2020: 449-451

LETTERS TO THE EDITOR

Cryo-EM structures of human pannexin 1 channel 

Qiuheng Jin^1,† , Bo Zhang^1,† , Xiang Zheng^2,† , Ningning Li^3,† , Lingyi Xu^4,5 , Yuan Xie^4,5 , Fangjun Song^4,5 , Eijaz Ahmed Bhat¹ , Yuan Chen² , Ning Gao³ , Jiangtao Guo^4,5,* , Xiaokang Zhang^6,* , Sheng Ye^1,6,*

¹Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China
²The State Key Laboratory of Subtropical Silviculture, Zhejiang A & F University, 666 Wusu street, Hangzhou, Zhejiang 311300, China
³State Key Laboratory of Membrane Biology, PekingTsinghua Center for Life Sciences, School of Life Sciences, Peking University, Beijing, China
⁴Department of Biophysics, Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
⁵Department of Biophysics, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
⁶Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, China
^†These authors contributed equally
Correspondence: Jiangtao Guo(jiangtaoguo@zju.edu.cn)Xiaokang Zhang(inter1965@qq.com)Sheng Ye(sye@tju.edu.cn)

Dear Editor,

Pannexin 1 (PANX1) channel mediates adenosine-5′-triphosphate (ATP) release for purinergic signaling,1 playing important roles in multiple physiological and pathological processes including apoptotic clearance,2 inflammatory response,3 cancer progression, and metastasis.4 Diverse stimuli have been reported to activate PANX1 channel, such as voltage, membrane stretch, hypotonicity, elevated extracellular K+ or intracellular Ca2+ concentration, C-terminal cleavage and phosphorylation.1,5 It is perplexing that PANX1 has been demonstrated to exhibit different unitary channel properties depending on the mode of activation.1,5 Particularly, PANX1 undergoes a stepwise, quantized activation progress upon sequentially cleaving the C-terminal of each subunit.6

https://doi.org/10.1038/s41422-020-0310-0

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