Volume 30, No 6, Jun 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 6, June 2020: 463-464

RESEARCH HIGHLIGHTS

Gasdermins deliver a deadly punch to cancer

Cheng Shen^1,† , Abhimanu Pandey^1,† , Si Ming Man^1,*

¹Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, ACT, Canberra, Australia
^†These authors contributed equally
Correspondence: Si Ming Man(siming.man@anu.edu.au)

The pore-forming gasdermin proteins mediate a lytic and pro-inflammatory form of cell death called pyroptosis and have been linked to the host defense against infection. Two recent studies published in Nature revealed that induction of pyroptosis in tumor cells promotes anti-tumor activity, highlighting gasdermins as potential new targets in cancer immunotherapy.

https://doi.org/10.1038/s41422-020-0316-7

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