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Volume 30, No 6, Jun 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 6, June 2020: 457-458

RESEARCH HIGHLIGHTS

Forks in the road to the first hematopoietic stem cells

Elizabeth D. Howell1,2 , Nancy A. Speck1,*

1Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
2Graduate Group in Cell and Molecular Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Correspondence: Nancy A. Speck(nancyas@upenn.edu)

Hou et al. examine the origin of hemogenic endothelial cells (HECs) by single-cell RNA sequencing. They show that arterial endothelial cells and HECs are derived from a common early arterial endothelial cell precursor, and that some HECs and their immediate progeny retain the capacity to generate both endothelial and hematopoietic cells longer than previously thought.


https://doi.org/10.1038/s41422-020-0331-8

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