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Submit Manuscript Volume 30, No 6, Jun 2020
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 30 Issue 6, June 2020: 457-458
Forks in the road to the first hematopoietic stem cells
Elizabeth D. Howell1,2 , Nancy A. Speck1,*
1Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USAHou et al. examine the origin of hemogenic endothelial cells (HECs) by single-cell RNA sequencing. They show that arterial endothelial cells and HECs are derived from a common early arterial endothelial cell precursor, and that some HECs and their immediate progeny retain the capacity to generate both endothelial and hematopoietic cells longer than previously thought.
https://doi.org/10.1038/s41422-020-0331-8